Synthesis of Thiazolidinedione Compound Library

Design, synthesis, and biological evaluation of a biyouyanagin compound library.

Modern drug discovery efforts rely, to a large extent, on lead compounds from two classes of small organic molecules; namely, natural products (i.e., secondary metabolites) and designed compounds (i.e., synthetic molecules). In this article, we demonstrate how these two domains of lead compounds can be merged through total synthesis and molecular design of analogs patterned after the targeted n...

French/European academic compound library initiative.

Since the year 2000, French academic medicinal chemists took the initiative to collect molecules and natural extracts produced in their labs over the past years to catalyse scientific partnerships with biologists through virtual and experimental screening. This formatted collection was named ‘Chimiothèque Nationale’ (National Compound Library). After eight years of existence, the outcome in ter...

Sample Handling - Weighting, Plating, Compound Library Management

Studies on the Synthesis of Novel 2,4-Thiazolidinedione Derivatives with Antidiabetic Activity

      A new series of thiazolidinedione derivatives were synthesized. The structures of these compounds were established by means of IR, 1H-NMR and elemental analysis. All of the compounds were screened for antidiabetic activity on albino rats. Most of the compounds showed significant antidiabetic activity when compared with the standard drug glibenclamide.

Synthesis and Antimicrobial Evaluation of N-Substituted-5- Benzylidene-2,4-Thiazolidinedione Derivatives

      A series of N-substituted-2,4-thiazolidinedione derivatives (TZDs) were prepared via N-alkylation of 2,4-TZD at position 3 using substituted benzyl halides. Synthesized N-substituted-2,4-TZD was then substituted at position 5 with substituted aromatic aldehyde according to Knoevenagel condensation method. Structures of the compounds were elucidated using various spectral techniques viz. I...